Eastern Colorado Geriatric Research, Education and Clinical Center (EC-GRECC) - VA Eastern Colorado Health Care System
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Eastern Colorado Geriatric Research, Education and Clinical Center (EC-GRECC)

 

Eastern Colorado GRECC Investigators


19 October 2020

 

Wendy M. Kohrt, PhD
Title: Associate Director for Research
Contact: wendy.kohrt@cuanschutz.edu
 
Personal Statement
I have received continuous funding from the NIH as a principal investigator since 1990. My career has been devoted to clinical research involving exercise, nutrition, hormone, and/or pharmacologic interventions focused on various aspects of metabolism in young and older adults. I have been the Director of Research for the Division of Geriatric Medicine since 1999, and in 2014 I became the Associate Director of Research for the new Eastern Colorado VA Geriatric Research, Education, and Clinical Center (GRECC). I am currently the PI for U54, U01, and R01 awards from the NIH and a co-investigator for several NIH and VA grants. I have more than 230 original and solicited research publications. I hold several administrative positions, including: Director of the Energy Balance Assessment Core Laboratory in the Colorado Nutrition and Obesity Research Center (NORC); Associate Director of the Colorado Clinical and Translational Sciences Institute (CCTSI), and Associate Director of the Center for Women’s Health Research (CWHR).
 
Since moving to the University of Colorado in 1999, I have served as primary research mentor for 20 postdoctoral fellows (11 PhD, 9 MD) and as a co-mentor for 25 postdoctoral fellows (15 PhD, 10 MD). Of my primary trainees, all but 3 advanced their careers in academic research and the majority of them have received major independent research support. Five of my current trainees (2 PhD, 3 MD), who are in the Divisions of Geriatric Medicine, Endocrinology, and Cardiology, hold NIH K awards. I am currently a senior faculty mentor for four T32 programs (Integrative Physiology of Aging; Obesity and Cardiovascular Disease; Training Program in Nutrition; Renal and Electrolyte Disease and Hypertension) and three K programs (Building Interdisciplinary Research Careers in Women’s Health; Women’s Reproductive Health Research Career Development; CCTSI KL2 Scholars).
 
Mentoring Activities
I view my activity as a research mentor as one of my important contributions to science. Since 1991, I have mentored or co-mentored 35 PhD-trained and 23 MD-trained research fellows from several departments/divisions (Geriatric Medicine, General Internal Medicine, Endocrinology, Infectious Diseases, Cardiology); the majority have established independent research careers. I serve as a senior faculty mentor on the following institutional training grants: Integrative Physiology of Aging (T32 AG000279); Nutrition (T32 DK007658); Obesity and Cardiovascular Disease (T32 HL116276); Colorado Building Interdisciplinary Research Careers in Women’s Health (K12 HD057022); and Colorado WHRH Career Development Center (K12 HD001271). I have served as mentor or co-mentor for 28 postdoctoral fellows supported by a T32 award, 8 supported by an F32 award, and 18 supported by a K award.

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Recent Publications

 

Jurić J, Kohrt WM, Kifer D, Gavin KM, Pezer M, Nigrovic PA, Lauc G. Effects of estradiol on biological age measured using the glycan age index. Aging (Albany NY). 2020 Oct 13;12. doi: 10.18632/aging.104060. Epub ahead of print.
PMID: 33049709.

Swanson CM, Blatchford PJ, Stone KL, Cauley JA, Lane NE, Rogers-Soeder TS, Redline S, Bauer DC, Wright KP Jr, Wierman ME, Kohrt WM, Orwoll ES; Osteoporotic Fractures in Men (MrOS) Study. Sleep duration and bone health measures in older men. Osteoporos Int. 2020 Sep 15. doi: 10.1007/s00198-020-05619-2. Epub ahead of print.
PMID: 32930851.

Moreau KL, Hildreth KL, Klawitter J, Blatchford P, Kohrt WM. Decline in endothelial function across the menopause transition in healthy women is related to decreased estradiol and increased oxidative stress. Geroscience. 2020 Aug 08.
PMID: 32770384.

Jankowski CM, Mawhinney S, Wilson MP, Campbell TB, Kohrt WM, Schwartz RS, Brown TT, Erlandson KM. Body Composition Changes in Response to Moderate or High-Intensity Exercise Among Older Adults with or without HIV Infection. J Acquir Immune Defic Syndr. 2020 Jul 16.
PMID: 32701826.

Swanson CM, Shea SA, Kohrt WM, Wright KP, Cain SW, Munch M, Vujovic N, Czeisler CA, Orwoll ES, Buxton OM. Sleep Restriction With Circadian Disruption Negatively Alter Bone Turnover Markers in Women. J Clin Endocrinol Metab. 2020 Jul 01; 105(7).
PMID: 32364602.

Cornwell WK, Tran T, Cerbin L, Coe G, Muralidhar A, Hunter K, Altman N, Ambardekar AV, Tompkins C, Zipse M, Schulte M, O'Gean K, Ostertag M, Hoffman J, Pal JD, Lawley JS, Levine BD, Wolfel E, Kohrt WM, Buttrick P. New insights into resting and exertional right ventricular performance in the healthy heart through real-time pressure-volume analysis. J Physiol. 2020 Jul; 598(13):2575-2587.
PMID: 32347547.

Kumar TR, Reusch JEB, Kohrt WM, Regensteiner JG. Sex Differences Across the Lifespan: A Focus on Cardiometabolism. J Womens Health (Larchmt). 2020 Jul; 29(7):899-909.
PMID: 32423340.

Park YM, Jankowski CM, Ozemek C, Hildreth KL, Kohrt WM, Moreau KL. Appendicular lean mass is lower in late compared with early perimenopausal women: potential role of FSH. J Appl Physiol (1985). 2020 May 01; 128(5):1373-1380.
PMID: 32298212.

Ozemek C, Hildreth KL, Blatchford PJ, Hurt KJ, Bok R, Seals DR, Kohrt WM, Moreau KL. Effects of resveratrol or estradiol on postexercise endothelial function in estrogen-deficient postmenopausal women. J Appl Physiol (1985). 2020 Apr 01; 128(4):739-747.
PMID: 32134713.

Harper SA, Baptista LC, Roberts LM, Wherry SJ, Boxer RS, Hildreth KL, Seay RS, Allman PH, Carter CS, Aban I, Kohrt WM, Buford TW. Angiotensin Converting Enzyme Inhibitors Combined with Exercise for Hypertensive Seniors (The ACES Trial): Study Protocol of a Randomized Controlled Trial. Front Med (Lausanne). 2019; 6:327.
PMID: 32039215.

Patnaik JL, Lynch AM, Wagner BD, Echalier EL, Kohrt WM, Mathias MT, Siringo FS, Palestine AG, Mandava N. Hormone Therapy as a Protective Factor for Age-Related Macular Degeneration. Ophthalmic Epidemiol. 2020 04; 27(2):148-154.
PMID: 31813321.

Beqollari D, Kohrt WM, Bannister RA. Equivalent L-type channel (CaV1.1) function in adult female and male mouse skeletal muscle fibers. Biochem Biophys Res Commun. 2020 Feb 19; 522(4):996-1002.
PMID: 31812241.

Kohrt WM, Wolfe P, Sherk VD, Wherry SJ, Wellington T, Melanson EL, Swanson CM, Weaver CM, Boxer RS. Dermal Calcium Loss Is Not the Primary Determinant of Parathyroid Hormone Secretion during Exercise. Med Sci Sports Exerc. 2019 10; 51(10):2117-2124.
PMID: 31009423.

Huebschmann AG, Huxley RR, Kohrt WM, Zeitler P, Regensteiner JG, Reusch JEB. Sex differences in the burden of type 2 diabetes and cardiovascular risk across the life course. Diabetologia. 2019 10; 62(10):1761-1772.
PMID: 31451872.

Swanson CM, Kohrt WM, Wolfe P, Wright KP, Shea SA, Cain SW, Munch M, Vujovic N, Czeisler CA, Orwoll ES, Buxton OM. Rapid suppression of bone formation marker in response to sleep restriction and circadian disruption in men. Osteoporos Int. 2019 Dec; 30(12):2485-2493.
PMID: 31446439.

Berman ESF, Swibas T, Kohrt WM, Catenacci VA, Creasy SA, Melanson EL, Speakman JR. Maximizing precision and accuracy of the doubly labeled water method via optimal sampling protocol, calculation choices, and incorporation of 17O measurements. Eur J Clin Nutr. 2020 Mar; 74(3):454-464.
PMID: 31427762.

Wherry SJ, Swanson CM, Wolfe P, Wellington T, Boxer RS, Schwartz RS, Kohrt WM. Bone Biomarker Response to Walking under Different Thermal Conditions in Older Adults. Med Sci Sports Exerc. 2019 08; 51(8):1599-1605.
PMID: 31083027.

Swanson CM, Blatchford PJ, Orwoll ES, Cauley JA, LeBlanc ES, Fink HA, Wright KP, Wierman ME, Kohrt WM, Stone KL. Association between objective sleep duration and bone mineral density in older postmenopausal women from the Study of Osteoporotic Fractures (SOF). Osteoporos Int. 2019 Oct; 30(10):2087-2098.
PMID: 31139855.

Shah VN, Joshee P, Sippl R, Pyle L, Vigers T, Carpenter RD, Kohrt W, Snell-Bergeon JK. Type 1 diabetes onset at young age is associated with compromised bone quality. Bone. 2019 06; 123:260-264.
PMID: 30936041.

Park YM, Keller AC, Runchey SS, Miller BF, Kohrt WM, Van Pelt RE, Kang C, Jankowski CM, Moreau KL. Acute estradiol treatment reduces skeletal muscle protein breakdown markers in early- but not late-postmenopausal women. Steroids. 2019 06; 146:43-49.
PMID: 30928279.

Keller AC, Klawitter J, Hildreth KL, Christians U, Putnam K, Kohrt WM, Reusch JEB, Moreau KL. Elevated plasma homocysteine and cysteine are associated with endothelial dysfunction across menopausal stages in healthy women. J Appl Physiol (1985). 2019 06 01; 126(6):1533-1540.
PMID: 30896357.

Ross R, Goodpaster BH, Koch LG, Sarzynski MA, Kohrt WM, Johannsen NM, Skinner JS, Castro A, Irving BA, Noland RC, Sparks LM, Spielmann G, Day AG, Pitsch W, Hopkins WG, Bouchard C. Precision exercise medicine: understanding exercise response variability. Br J Sports Med. 2019 Sep; 53(18):1141-1153.
PMID: 30862704.

Jankowski CM, Wolfe P, Schmiege SJ, Nair KS, Khosla S, Jensen M, von Muhlen D, Laughlin GA, Kritz-Silverstein D, Bergstrom J, Bettencourt R, Weiss EP, Villareal DT, Kohrt WM. Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials. Clin Endocrinol (Oxf). 2019 02; 90(2):293-300.
PMID: 30421439.

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