Eastern Colorado Geriatric Research, Education and Clinical Center (EC-GRECC) - VA Eastern Colorado Health Care System
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Eastern Colorado Geriatric Research, Education and Clinical Center (EC-GRECC)


Eastern Colorado GRECC Investigators

21 December 2020


Edward L. Melanson, PhD
Title: Professor, Division of Endocrinology, Metabolism and Diabetes
Contact: ed.melanson@cuanschutz.edu
Personal Statement
I am a Professor of Medicine in the Division of Endocrinology, Metabolism and Diabetes, with a joint appointment in the Division of Geriatric Medicine. I have maintained consistent NIH funding since 2001, and have received continuous funding from the NIH as a principle investigator since 2007. I conduct clinical research to study the effects of lifestyle interventions (physical activity, diet, and sleep) on bioenergetics (energy and substrate metabolism, and physical activity). I have substantial expertise in measuring energy metabolism, physical activity, and sedentary behavior in humans, using whole-room indirect calorimetry, doubly labeled water, and a variety of accelerometry-based physical activity monitors. More recently, I have been a COI on studies (R43DK09336, R44 DK093362) aimed at using a novel approach to improve the precision and reduce the costs of performing DLW analysis.
Research Interest
My early research was focused on developing and validating objective methods for measuring physical activity and energy expenditure in free-living humans. These studies stemmed from the need to develop more sensitive and less obtrusive means of assessing the associations between physical activity behavior and various health outcomes. Early research in this area relied on self-report, which has numerous limitations, including recall errors, bias, and lack of objectivity. I developed the first model that used accelerometer data to distinguish different intensities of physical activity. This line of research has remained one of my primary areas of interest, and has expanded to include the development of new methods to measure energy expenditure using whole-room indirect calorimetry, and the development and validation of new methods of measuring free-living energy expenditure. These studies include novel instrumentation, such as measures of heat flux as a means of measuring energy expenditure, and validation of a laser-based instrument to measure isotopic enrichments in urine samples. This latter line of research is aimed at developing and validating a novel approach to improve the precision of performing measurement of isotopic enrichments in urine (R43 DK09336, R44 DK093362). We have shown this instrument to be accurate compared to the gold-standard measurement of whole-room indirect calorimetry, as well as against an independent Isotope Ratio Mass Spectrometry Laboratory. Collectively, my research has expanded methods of assessing physical activity in humans, and will ultimately lead to lower-cost, accurate and objective means of assessing physical activity and energy expenditure in in free-living humans.

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Recent Publications


Miller MJ, Blankenship JM, Kline PW, Melanson EL, Christiansen CL. Patterns of Sitting, Standing, and Stepping After Lower Limb Amputation. Phys Ther. 2020 Dec 17:pzaa212. doi: 10.1093/ptj/pzaa212. Epub ahead of print.
PMID: 33336706.

Gavin KM, Melanson EL, Hildreth KL, Gibbons E, Bessesen DH, Kohrt WM. A Randomized Controlled Trial of Ovarian Suppression in Premenopausal Women: No Change in Free-Living Energy Expenditure. Obesity (Silver Spring). 2020 Nov;28(11):2125-2133. doi: 10.1002/oby.22978.
PMID: 33150745.

Chen KY, Smith S, Ravussin E, et al. Room Indirect Calorimetry Operating and Reporting Standards (RICORS 1.0): A Guide to Conducting and Reporting Human Whole-Room Calorimeter Studies. Obesity (Silver Spring). 2020;28(9):1613-1625. doi:10.1002/oby.22928
PMID: 32841524.

Melanson EL, Chen KY. Letter to the Editor from Melanson et al (second letter): "Twice as High Diet-Induced Thermogenesis After Breakfast vs Dinner on High-Calorie as Well as Low-Calorie Meals". J Clin Endocrinol Metab. 2020 Aug 01; 105(8).
PMID: 32485743.

Depner CM, Cogswell DT, Bisesi PJ, Markwald RR, Cruickshank-Quinn C, Quinn K, Melanson EL, Reisdorph N, Wright KP. Developing preliminary blood metabolomics-based biomarkers of insufficient sleep in humans. Sleep. 2020 Jul 13; 43(7).
PMID: 31894238.

Melanson EL, Chen KY. Letter to the Editor: "Twice as High Diet-Induced Thermogenesis After Breakfast vs Dinner on High-Calorie as Well as Low-Calorie Meals". J Clin Endocrinol Metab. 2020 Jul 01; 105(7).
PMID: 32300812.

Sanford JA, Nogiec CD, Lindholm ME, Adkins JN, Amar D, Dasari S, Drugan JK, Fernández FM, Radom-Aizik S, Schenk S, Snyder MP, Tracy RP, Vanderboom P, Trappe S, Walsh MJ; Molecular Transducers of Physical Activity Consortium. Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise. Cell. 2020 Jun 25;181(7):1464-1474. doi: 10.1016/j.cell.2020.06.004.
PMID: 32589957.

Caldwell AE, Zaman A, Ostendorf DM, Pan Z, Swanson BB, Phelan S, Wyatt HR, Bessesen DH, Melanson EL, Catenacci VA. Impact of Combined Hormonal Contraceptive Use on Weight Loss: A Secondary Analysis of a Behavioral Weight-Loss Trial. Obesity (Silver Spring). 2020 06; 28(6):1040-1049.
PMID: 32441474.

Stothard ER, Ritchie HK, Birks BR, Eckel RH, Higgins J, Melanson EL, Wright KP, McHill AW. Early Morning Food Intake as a Risk Factor for Metabolic Dysregulation. Nutrients. 2020 Mar 13; 12(3).
PMID: 32182981.

Giles ED, Brown IL, MacLean PS, Pan Z, Melanson EL, Heard KJ, Cornier MA, Marden T, Higgins JA. The In Vivo Net Energy Content of Resistant Starch and Its Effect on Macronutrient Oxidation in Healthy Adults. Nutrients. 2019 Oct 16; 11(10).
PMID: 31623184.

Rynders CA, Thomas EA, Zaman A, Pan Z, Catenacci VA, Melanson EL. Effectiveness of Intermittent Fasting and Time-Restricted Feeding Compared to Continuous Energy Restriction for Weight Loss. Nutrients. 2019 Oct 14; 11(10).
PMID: 31614992.

Kohrt WM, Wolfe P, Sherk VD, Wherry SJ, Wellington T, Melanson EL, Swanson CM, Weaver CM, Boxer RS. Dermal Calcium Loss Is Not the Primary Determinant of Parathyroid Hormone Secretion during Exercise. Med Sci Sports Exerc. 2019 10; 51(10):2117-2124.
PMID: 31009423.

Catenacci VA, Ostendorf DM, Pan Z, Bing K, Wayland LT, Seyoum E, Stauffer BL, Phelan S, Creasy SA, Caldwell AE, Wyatt HR, Bessesen DH, Melanson EL. The Impact of Timing of Exercise Initiation on Weight Loss: An 18-Month Randomized Clinical Trial. Obesity (Silver Spring). 2019 11; 27(11):1828-1838.
PMID: 31565869.

Berman ESF, Swibas T, Kohrt WM, Catenacci VA, Creasy SA, Melanson EL, Speakman JR. Maximizing precision and accuracy of the doubly labeled water method via optimal sampling protocol, calculation choices, and incorporation of 17O measurements. Eur J Clin Nutr. 2020 Mar; 74(3):454-464.
PMID: 31427762.

Willis EA, Creasy SA, Honas JJ, Melanson EL, Donnelly JE. The effects of exercise session timing on weight loss and components of energy balance: midwest exercise trial 2. Int J Obes (Lond). 2020 01; 44(1):114-124.
PMID: 31289334.

Creasy SA, Crane TE, Garcia DO, Thomson CA, Kohler LN, Wertheim BC, Baker LD, Coday M, Hale L, Womack CR, Wright KP, Melanson EL. Higher amounts of sedentary time are associated with short sleep duration and poor sleep quality in postmenopausal women. Sleep. 2019 07 08; 42(7).
PMID: 30994175.

Presby DM, Jackman MR, Rudolph MC, Sherk VD, Foright RM, Houck JA, Johnson GC, Orlicky DJ, Melanson EL, Higgins JA, MacLean PS. Compensation for cold-induced thermogenesis during weight loss maintenance and regain. Am J Physiol Endocrinol Metab. 2019 05 01; 316(5):E977-E986.
PMID: 30912962.

Ostendorf DM, Caldwell AE, Creasy SA, Pan Z, Lyden K, Bergouignan A, MacLean PS, Wyatt HR, Hill JO, Melanson EL, Catenacci VA. Physical Activity Energy Expenditure and Total Daily Energy Expenditure in Successful Weight Loss Maintainers. Obesity (Silver Spring). 2019 03; 27(3):496-504.
PMID: 30801984.

Depner CM, Melanson EL, Eckel RH, Snell-Bergeon JK, Perreault L, Bergman BC, Higgins JA, Guerin MK, Stothard ER, Morton SJ, Wright KP. Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep. Curr Biol. 2019 03 18; 29(6):957-967.e4.
PMID: 30827911.

De Jong NP, Rynders CA, Goldstrohm DA, Pan Z, Lange AH, Mendez C, Melanson EL, Bessesen DH, Bergouignan A. Effect of frequent interruptions of sedentary time on nutrient metabolism in sedentary overweight male and female adults. J Appl Physiol (1985). 2019 04 01; 126(4):984-992.
PMID: 30629473.

Kline PW, Melanson EL, Sullivan WJ, Blatchford PJ, Miller MJ, Stevens-Lapsley JE, Christiansen CL. Improving Physical Activity Through Adjunct Telerehabilitation Following Total Knee Arthroplasty: Randomized Controlled Trial Protocol. Phys Ther. 2019 01 01; 99(1):37-45.
PMID: 30329126.

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