Eastern Colorado Geriatric Research, Education and Clinical Center (GRECC) - VA Eastern Colorado Health Care System
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Eastern Colorado Geriatric Research, Education and Clinical Center (GRECC)


Eastern Colorado GRECC Investigators

20 December 2019

Biography | Recent Publications

Edward L. Melanson, PhD
Title: Professor, Division of Endocrinology, Metabolism and Diabetes
Contact: ed.melanson@cuanschutz.edu
Personal Statement
I am a Professor of Medicine in the Division of Endocrinology, Metabolism and Diabetes, with a joint appointment in the Division of Geriatric Medicine. I have maintained consistent NIH funding since 2001, and have received continuous funding from the NIH as a principle investigator since 2007. I conduct clinical research to study the effects of lifestyle interventions (physical activity, diet, and sleep) on bioenergetics (energy and substrate metabolism, and physical activity). I have substantial expertise in measuring energy metabolism, physical activity, and sedentary behavior in humans, using whole-room indirect calorimetry, doubly labeled water, and a variety of accelerometry-based physical activity monitors. More recently, I have been a COI on studies (R43DK09336, R44 DK093362) aimed at using a novel approach to improve the precision and reduce the costs of performing DLW analysis.
My early research was focused on developing and validating objective methods for measuring physical activity and energy expenditure in free-living humans. These studies stemmed from the need to develop more sensitive and less obtrusive means of assessing the associations between physical activity behavior and various health outcomes. Early research in this area relied on self-report, which has numerous limitations, including recall errors, bias, and lack of objectivity. I developed the first model that used accelerometer data to distinguish different intensities of physical activity. This line of research has remained one of my primary areas of interest, and has expanded to include the development of new methods to measure energy expenditure using whole-room indirect calorimetry, and the development and validation of new methods of measuring free-living energy expenditure. These studies include novel instrumentation, such as measures of heat flux as a means of measuring energy expenditure, and validation of a laser-based instrument to measure isotopic enrichments in urine samples. This latter line of research is aimed at developing and validating a novel approach to improve the precision of performing measurement of isotopic enrichments in urine (R43 DK09336, R44 DK093362). We have shown this instrument to be accurate compared to the gold-standard measurement of whole-room indirect calorimetry, as well as against an independent Isotope Ratio Mass Spectrometry Laboratory. Collectively, my research has expanded methods of assessing physical activity in humans, and will ultimately lead to lower-cost, accurate and objective means of assessing physical activity and energy expenditure in in free-living humans.

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Recent Publications

 Pub: The effects of exercise session timing on weight loss and components of energy balance: midwest exercise trial 2
9 July 2019 - The authors of this paper include Ed Melanson, PhD, FACSM of Eastern Colorado GRECC and CU SOM School of Physical Therapy. The study explores whether the time of day that a person exercises relates to the amount of weight loss they experience. Specifically did overweight/obese individuals who exercise in the morning compared to those who exercise late afternoon/early evening experience weight loss over a 10-month period. Persons who exercised sporadically, that is some morning and some later were also compared. It is unclear why it happens but those exercising early or on an early/late schedule lost significantly more weight than those who exercise later in the day. Read more.

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