VA Eastern Colorado Health Care System
Eastern Colorado Geriatric Research, Education and Clinical Center (EC-GRECC)
Eastern Colorado GRECC Investigators
9 November 2020
Kerrie Moreau, PhD
- Title: Professor, Geriatric Medicine
- Contact: email@example.com
- Personal Statement
I have been conducting clinical research studies focusing on sex hormones, exercise and cardiovascular aging for 20 years. My laboratory investigates the mechanisms underlying vascular protection of gonadal hormones, including how declines in ovarian function during the menopause transition, and low testosterone in aging men, contributes to an acceleration in cardiovascular aging, as characterized by endothelial dysfunction, arterial stiffening. intimal-medial thickening and cardiac dysfunction. As an exercise physiologist, we also investigate the modulatory influence of sex hormones on cardiovascular adaptations to habitual exercise. My laboratory uses a variety of experimental techniques and skills to study the integrative biology of the aging vasculature in humans, which has allowed me to develop a successful clinical research program to study the mechanisms underlying sex hormone deficiency and vascular aging in humans.
- Research Interest
My translational research approach includes ultrasound imaging to examine the arteries and heart, gonadal suppression interventions to isolate the role of sex hormones, infusion models to isolate the influence of oxidative stress, and endothelial cell harvests from peripheral veins and arteries to determine cellular mechanisms. I am currently the PI on an NIH R01 award investigating the cardiovascular consequences of low testosterone in older men and its contributions to Alzheimer’s Disease risk and its related dementias in middle-aged and older men. Additionally, I am the Director of the Cardiovascular BioImaging Core at the University of Colorado Denver Anschutz Medical Campus which is a dedicated research facility for protocols utilizing cardiovascular imaging. In summary, I have demonstrated a productive record in carrying out clinical research studies that impact public health.
Babcock MC, DuBose LE, Witten TL, Brubaker A, Stauffer BL, Hildreth KL, Moreau KL. Assessment of macro and microvascular function in aging males. J Appl Physiol (1985). 2020 Nov 5. doi: 10.1152/japplphysiol.00616.2020. Epub ahead of print.
Brunette AM, Warner K, Holm KE, Meschede K, Wamboldt FS, Kozora E, Moser DJ, Make BJ, Crapo JD, Moreau KL, Weinberger HD, Bowler R, Hoth KF. Daily Activities: The Impact of COPD and Cognitive Dysfunction. Arch Clin Neuropsychol. 2020 Oct 26:acaa090. doi: 10.1093/arclin/acaa090. Epub ahead of print.
Moreau KL, Hildreth KL, Klawitter J, Blatchford P, Kohrt WM. Decline in endothelial function across the menopause transition in healthy women is related to decreased estradiol and increased oxidative stress. Geroscience. 2020 Aug 08.
Hoth KF, Moreau KL, Weinberger HD, Holm KE, Meschede K, Crapo JD, Make BJ, Moser DJ, Kozora E, Bowler RP, Pierce GL, Ten Eyck P, Wamboldt FS. Carotid Artery Stiffness is Associated With Cognitive Performance in Former Smokers With and Without Chronic Obstructive Pulmonary Disease. J Am Heart Assoc. 2020 May 05; 9(9):e014862.
Park YM, Jankowski CM, Ozemek C, Hildreth KL, Kohrt WM, Moreau KL. Appendicular lean mass is lower in late compared with early perimenopausal women: potential role of FSH. J Appl Physiol (1985). 2020 May 01; 128(5):1373-1380.
Moreau KL, Babcock MC, Hildreth KL. Sex differences in vascular aging in response to testosterone. Biol Sex Differ. 2020 04 15; 11(1):18.
Ozemek C, Hildreth KL, Blatchford PJ, Hurt KJ, Bok R, Seals DR, Kohrt WM, Moreau KL. Effects of resveratrol or estradiol on postexercise endothelial function in estrogen-deficient postmenopausal women. J Appl Physiol (1985). 2020 Apr 01; 128(4):739-747.
Nokoff NJ, Scarbro SL, Moreau KL, Zeitler P, Nadeau KJ, Juarez-Colunga E, Kelsey MM. Body Composition and Markers of Cardiometabolic Health in Transgender Youth Compared With Cisgender Youth. J Clin Endocrinol Metab. 2020 Mar 01; 105(3).
Croghan A, Brunette A, Holm KE, Kozora E, Moser DJ, Wamboldt FS, Meschede K, Make BJ, Crapo JD, Weinberger HD, Moreau KL, Bowler RP, Hoth KF. Reduced Attention in Former Smokers with and without COPD. Int J Behav Med. 2019 Dec; 26(6):600-607.
Seals DR, Nagy EE, Moreau KL. Aerobic exercise training and vascular function with ageing in healthy men and women. J Physiol. 2019 10; 597(19):4901-4914.
Moreau KL, DuBose LE. The role of androgens in microvascular endothelial dysfunction in polycystic ovary syndrome: does size matter? J Physiol. 2019 06; 597(11):2829-2830.
Van Hove JLK, Freehauf CL, Ficicioglu C, Pena LDM, Moreau KL, Henthorn TK, Christians U, Jiang H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler SP, Spector EB, Kronquist KE, Thomas JA, Emmett P, Harrington MJ, Pyle L, Creadon-Swindell G, Wempe MF, MacLean KN. Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine ß-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial. J Inherit Metab Dis. 2019 05; 42(3):424-437.
Park YM, Keller AC, Runchey SS, Miller BF, Kohrt WM, Van Pelt RE, Kang C, Jankowski CM, Moreau KL. Acute estradiol treatment reduces skeletal muscle protein breakdown markers in early- but not late-postmenopausal women. Steroids. 2019 06; 146:43-49.
Keller AC, Klawitter J, Hildreth KL, Christians U, Putnam K, Kohrt WM, Reusch JEB, Moreau KL. Elevated plasma homocysteine and cysteine are associated with endothelial dysfunction across menopausal stages in healthy women. J Appl Physiol (1985). 2019 06 01; 126(6):1533-1540.
Moreau KL. Modulatory influence of sex hormones on vascular aging. Am J Physiol Heart Circ Physiol. 2019 03 01; 316(3):H522-H526.