Eastern Colorado Geriatric Research, Education and Clinical Center (GRECC) - VA Eastern Colorado Health Care System
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Eastern Colorado Geriatric Research, Education and Clinical Center (GRECC)

 

Eastern Colorado GRECC Investigators

20 December 2019

Biography

Kerrie Moreau, PhD
Title: Professor, Geriatric Medicine
Contact: kerrie.moreau@cuanschutz.edu
 
Personal Statement
I have been conducting clinical research studies focusing on sex hormones, exercise and cardiovascular aging for 20 years. My laboratory investigates the mechanisms underlying vascular protection of gonadal hormones, including how declines in ovarian function during the menopause transition, and low testosterone in aging men, contributes to an acceleration in cardiovascular aging, as characterized by endothelial dysfunction, arterial stiffening. intimal-medial thickening and cardiac dysfunction. As an exercise physiologist, we also investigate the modulatory influence of sex hormones on cardiovascular adaptations to habitual exercise. My laboratory uses a variety of experimental techniques and skills to study the integrative biology of the aging vasculature in humans, which has allowed me to develop a successful clinical research program to study the mechanisms underlying sex hormone deficiency and vascular aging in humans.
My translational research approach includes ultrasound imaging to examine the arteries and heart, gonadal suppression interventions to isolate the role of sex hormones, infusion models to isolate the influence of oxidative stress, and endothelial cell harvests from peripheral veins and arteries to determine cellular mechanisms. I am currently the PI on an NIH R01 award investigating the cardiovascular consequences of low testosterone in older men and its contributions to Alzheimer’s Disease risk and its related dementias in middle-aged and older men. Additionally, I am the Director of the Cardiovascular BioImaging Core at the University of Colorado Denver Anschutz Medical Campus which is a dedicated research facility for protocols utilizing cardiovascular imaging. In summary, I have demonstrated a productive record in carrying out clinical research studies that impact public health.

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